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Synvisc-One is a one-time hyaluronic acid injection for knee osteoarthritis that improves joint lubrication and cushioning, offering long-lasting pain relief and enhanced mobility.

Active Substances: HYLAN GF 20
Strength: 8ml
Pack Size: 1 x 6ml Pre-Filled Syringe

SKU: Synvisc One1 Categories: ,

Additional information

Synvisc-One Hylan G-F 20 is an advanced hyaluronic acid injection developed to provide sustained relief from osteoarthritis pain in the knee. It is composed of hylan G-F 20, a high molecular weight hyaluronan derivative that closely resembles the natural synovial fluid found in healthy joints. This single-injection treatment is designed to restore the viscoelastic properties of the synovial fluid, offering effective lubrication and cushioning to the affected joint.

Synvisc-One works by supplementing the degraded synovial fluid in osteoarthritic knees, thereby reducing friction and pain while improving joint function. It is administered as a one-time injection, providing the convenience of fewer doctor visits and the benefit of long-term pain relief. Clinical studies have shown that Synvisc-One Hylan G-F 20 can provide relief for up to six months, making it a preferred choice for patients seeking a non-surgical option to manage their osteoarthritis symptoms.

Indication and Applications

Synvisc-One is indicated for the treatment of pain associated with osteoarthritis of the knee in patients who have not responded adequately to conservative non-pharmacologic therapy and simple analgesics. It helps restore joint function and mobility by improving the lubrication and shock absorption properties of the synovial fluid.

Main Treatment Areas

  • Knee Joint: Synvisc-One is specifically designed for use in the knee joint to provide significant pain relief and improved mobility, reducing stiffness and discomfort.

Synvisc-One Hylan G-F 20 Key Benefits

  • Long-Lasting Relief: A single injection provides pain relief for up to six months.
  • Enhanced Lubrication: Mimics natural synovial fluid to improve joint function and reduce friction.
  • Convenient Single Injection: Reduces the need for multiple doctor visits.
  • Improved Mobility: Enhances overall joint health and movement, allowing patients to maintain an active lifestyle.


  • Hylan G-F 20: A derivative of hyaluronic acid that provides lubrication and cushioning to the joints. It is composed of hylan A and hylan B polymers suspended in a buffered physiological sodium chloride (salt) solution.

Use Instructions

  1. Before the Injection: Ensure the injection site is clean and disinfected.
  2. Administration: Synvisc-One should be administered by a trained healthcare professional, who will inject it directly into the knee joint.
  3. Post-Injection Care: Patients should avoid strenuous activities for at least 48 hours post-injection to allow the treatment to settle and achieve maximum benefit.

Is Synvisc the same as hyaluronic acid?

In essence, Synvisc is a specific medical product derived from hyaluronic acid but is enhanced and modified to provide better therapeutic benefits for osteoarthritis patients. It is not pure hyaluronic acid but a specialized form designed for medical use in joint injections.

Purchase Information

Synvisc-One is available in pre-filled syringes designed for single-use. For wholesale pricing and bulk order discounts, Synvisc-One can be purchased through reputable suppliers like Dr Sales Direct, ensuring product authenticity and quality. Clinics and healthcare providers benefit from competitive pricing and reliable supply when ordering in larger quantities.

Frequently Asked Questions

Both Synvisc and Synvisc-One are effective in treating knee osteoarthritis, offering similar efficacy and safety profiles. The main difference is in the dosing regimen: Synvisc requires three weekly injections, while Synvisc-One is a single-dose injection, providing greater convenience. The choice between them often depends on patient preference for fewer doctor visits and the convenience of a single injection​.

Yes, Synvisc-One has been shown to provide significant pain relief for knee osteoarthritis. Many patients experience relief starting from the first month after the injection, with effects lasting up to six months. Individual results can vary, and some patients might respond better than others.

Synvisc-One is not the same as pure hyaluronic acid, but it is derived from hyaluronic acid. Synvisc-One contains hylan G-F 20, a chemically modified form of hyaluronic acid, which helps provide lubrication and cushioning in the knee joint​.